Summary of the science
Stem cells possess the remarkable ability to self-renew and turn into different cell types with different functions. They are essential for development (e.g. different cell types are needed for different organ systems) and ensuring dead/unhealthy cells in adults are replaced with new cells. They have also been shown to play a part in diseases such as cancer. The specific path a stem cell takes to become a specialised cell is determined by its "cell fate." The Hochedlinger lab focuses on studying this decision-making process that decides whether a stem cell will renew itself or begin the specialisation journey.
About the research
The Hochedlinger lab investigates the role of stem cells in normal development and disease. They study how stem cells have the ability to self-renew and differentiate into mature cells (also known as cell fate). Stem cells play crucial roles in various processes, including development, tissue maintenance in adults, and recovery from injuries. The lab is particularly interested in understanding the factors that control the decision-making process between self-renewal and differentiation in embryonic stem cells, both in healthy conditions and in the context of diseases like cancer. By identifying and characterising these factors, they aim to gain insights into stem cell biology and harness their potential for therapeutic applications.
About the illustration