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Vivid Biology is on sabbatical until 2028
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Vivid Biology is on pause from 2025 to 2028. This is because Claudia is living in Madrid, Spain.

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Towards in vivo structural biology: solving protein structures using deep mutagenesis
Towards in vivo structural biology: solving protein structures using deep mutagenesis
Towards in vivo structural biology: solving protein structures using deep mutagenesis
2018
Ben Lehner

Summary of the science

It is important to know what proteins look like in 3D as their structure is important in determining their function. However, the structures of many proteins have yet to be identified. The Lehner Lab has developed a novel method for finding out the structures of many proteins which uses fewer techniques and apparatus and may potentially allow for function to be inferred also.

About the research

The Lehner Lab aim to understand how molecular changes affect biological systems. They take a quantitative and predictive approach to this, using large sequence libraries to model how variations at the DNA level affect protein structure and how this affects function and how well they perform this function. Part of their work is concerned with identifying the three-dimensional structures of previously unknown protein domains. They have developed a method of generating high-resolution characterisations of proteins by measuring the activity of mutant variants of proteins in question.

About the illustration