Summary of the science
There is s a special pathway called the Hedgehog pathway, which helps cells communicate with each other through signals. The lab was interested in how this pathway is connected to tiny particles called lipoproteins and special molecules called sterols. Lipoproteins help carry different types of fats, including cholesterol, through our bloodstream. They are like little vehicles that transport these fats to the places where they are needed in our cells. Lipoproteins have a special structure consisting of proteins and fats that allow them to move around in our body and deliver fats to the right places. Sterols are a type of molecule that are found in our bodies and in many other living organisms. Cholesterol is a well-known example of a sterol. These molecules are essential for the proper functioning of our cells. They play important roles in various processes, such as building the structure of cell membranes and helping with the production of certain hormones.
About the research
The lab led by Suzanne Eaton investigated the Hedgehog (Hh) signalling pathway and its association with lipoproteins and sterol metabolism. They study the cellular functions of Patched, a protein involved in Hh signalling, and explore how specific pathways deliver sterols, which are important molecules for cellular processes. By combining the fields of intracellular sterol trafficking and Hh studies, they aim to gain a more advanced understanding of the Hh signal transduction pathway and the cell biology of sterol metabolism.
About the illustration