Summary of the science
A gene is converted into a molecule known as mRNA before it is turned into protein. Some genes can produce different mRNA variations depending on how they are read (for example, certain letters could be missed out resulting in different information being passed on). This can result in different protein variations with different functions. One example of this are PRDM proteins and some variants can have anti-cancer effects but some may also promote cancer. The Guccione Lab is looking to see how these PRDM proteins work and how they can be used to fight against cancer.
About the research
Ernesto Guccione and his lab are interested in transcriptional and post-transcriptional regulation and how better understanding of the mechanisms involved can be used to inform cancer therapies. They are currently investigating the function of PRDM proteins which are transcription factors that can suppress or promote tumour formation. Their effects are dependent on which isoform is generated as a result of alternative splicing. The lab aims to understand how transcription can modify the properties of this protein and how it may be applied for therapeutic purposes.
About the illustration