Summary of the science
Cancer cells are known for their ability to grow and migrate and they possess several characteristics that make them experts in invasion. Actin is a family of proteins (like thin strands) that form the micro skeleton within cells. They can extend, retract and move, which, in turn, allows the whole cell to move and change shape - and essentially invade. The Parsons group have developed a new way to visualise cancer cells, making it easier to observe and investigate processes like this.
About the research
The Parsons Group seeks to understand the underlying mechanisms of adhesion and migration in cancer cells and the role it plays in tumorigenesis. They investigate processes like actin assembly and cellular signalling. The team have developed a method of 3D modelling which allows them to take reproducible and high-resolution images of cancer cell spheroids. This technique makes it easier to visualise molecular details and may be used in the future to model more complex in vitro systems.
About the illustration
We wanted to highlight the 3D imaging chamber method used by the research team, which allowed them to take high-quality, reproducible images of cancer cell spheroids. We used the symmetrical composition of the spheroids to suggest the appearance of an imaging chamber plate. To highlight the main research focus, the assembly of actin, and to suggest tumour growth, we had some of the spheroids protruding out of their chambers.