Generating neuronal diversity: stochastic or deterministic choices
2014
Claude Desplan
Summary of the science
Different types of choices are involved in the process of generating new brain cells (neurons). Claude Desplan's lab studies whether the process of generating these neurons involves random (stochastic) or fixed (deterministic) choices. Random choices would mean that the type of neuron that is created is determined by chance. It suggests that different neurons can have different characteristics or functions due to a random process during their development. However, fixed choices would mean that the type of neuron that is created is pre-determined and not random. It suggests that specific factors or instructions determine the characteristics or functions of neurons, leading to consistent and predictable outcomes.
About the research
Claude Desplan's lab focuses on understanding how different types of neurons are generated in the optic lobes, which play a crucial role in Drosophila's visual function. They investigate the process of neuronal diversity and the factors involved in making stochastic and deterministic choices during development. By studying the genetic networks and temporal patterning of transcription factors, they have identified the mechanisms by which different neurons are formed and the factors that determine their fate and survival. They also explore how spatial transcription factors contribute to neuronal diversity. Their research helps to unravel the complex processes that generate diverse neural circuits.
About the illustration
We wanted to show how different types of neurons are generated in the optic lobes in Drosophila. In order to not take away focus from the eye, we used black to illustrate an outline of the Drosophila head. We used different opacities and different sizes/shapes to represent the different types of neurons generated.