Summary of the science
DNA holds all of our genetic information, which is used to make proteins. Our cells need these proteins to function properly. When DNA gets injured, it can cause problems in our genetic material and therefore our proteins, affecting how our body functions. John Rouse and his team investigate the special proteins and mechanisms that help cells recognise and repair these damages. Understanding this process can help prevent genetic abnormalities and keep our DNA healthy, ensuring our bodies work properly.
FAN1 is a special protein that helps cells fix problems in our DNA. When our DNA replication process gets stuck or blocked, FAN1 comes to the rescue. It acts like a repair tool, helping to untangle and fix the damaged DNA so that it can continue working properly.
About the research
John Rouse's Research Group focuses on understanding the molecular mechanisms involved in the detection, signalling, and repair of damaged DNA. They study how cells respond to situations where DNA replication or transcription is hindered by DNA lesions, which can lead to genomic instability and problems in gene expression. Their research has identified key proteins involved in DNA repair, such as SLX4 and FAN1, and investigates their roles in promoting DNA repair and maintaining genome stability.
About the illustration