Summary of the science
The Akhtar lab studies a protein called MOF and how it can change the structure of our DNA. DNA holds all the genetic information required by our cells to make proteins and function properly, in small sections called genes. DNA is wrapped around proteins called histones, like spools of wool - they help DNA keep its structure. They found that MOF interacts with these histones. This causes certain genes to become more accessible and easier to turn on or off (this is called epigenetics). By understanding this process, they hope to learn more about how our genes work and how they can affect our bodies.
About the research
The Akhtar lab focuses on the lysine acetyltransferase MOF (KAT8) and its modification of histone H4 (H4K16ac). This modification directly influences chromatin structure, increasing accessibility. MOF is part of two chromatin-associated complexes, the MSL and NSL complexes, which are conserved in various organisms. The lab aims to understand the role of MOF and these complexes in gene regulation and chromatin organisation.
About the illustration