Summary of the science
Cells can form complex structures by themselves in a process known as self-organisation. Scientists have discovered that this principle can lead to cells forming tiny, three-dimensional, functioning cell systems in the lab. These are known as organoids - they behave similarly to real organs. Therefore, they are extremely useful in medical research, allowing scientists to freely experiment without having to utilise a human patient. However, organoid technology is still improving and more research is needed on how self-organisation works to reap the full benefits of this advancing field.
About the research
The Lütolf Lab studies the formation of organoids, self-sustaining tissue cultures made of stem cells that mimic real organs, which have extensive uses for medical and biological research. The key to this is understanding the principles of self-organisation to create long-lasting and sustainable cultures. Using bioengineering techniques, the lab aims to investigate the processes that occur in stem cells and manipulate them to improve organoid technology.
About the illustration
The focus of the research is how cells self-organise to form complex structures. The main theme of the illustration is therefore the spontaneous formation of a larger, more complex tissue, visible through a single cell proliferating to form a pattern resembling epithelial lining. This is emphasised by the repetition of this pattern.