Summary of the science
In our blood, there are amazing cells called killer cells that are capable of recognising and destroying infected and cancerous cells. These immune cells have specific genes that contribute to their lethal abilities, and it is important to understand the role of each gene. Cell polarity in lymphocytes, like cytotoxic T lymphocytes, means that their cellular components are organised in a specific way that helps them effectively recognise and destroy target cells by concentrating and releasing their killing substances at the right place. This research is important because new cancer treatments are using these killer cells, and by understanding how they work, we can develop better therapies.
About the research
Gillian Griffiths and her team focus on studying killer cells, specifically cytotoxic T lymphocytes. The lab has discovered new genes that are involved in the functioning of killer cells and aim to understand the role of each component within these cells. By studying killer cells lacking these new genes and using live imaging techniques, they can identify the differences and gain insights into how the cells function. Cell polarity in lymphocytes, such as cytotoxic T lymphocytes (CTLs), refers to the asymmetric organisation of cellular components that enables them to efficiently recognise and destroy target cells. This polarisation involves the precise concentration and secretion of cytolytic proteins at the immunological synapse, allowing CTLs to deliver a lethal hit directly to the target cell.
About the illustration