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Mitotic progression

Mitosis requires reorganisation of the whole cellular architecture, a process highly regulated by protein phosphorylation.

Mitosis is a step in cell division where the newly replicated chromosomes are pulled apart into two identical nuclei. This requires reorganisation of the whole cell, and therefore it must be tightly regulated.

Proteins in the cell can be controlled in many ways. One example is phosphorylation, a process where the amino acids of the protein are modified by adding a phosphate. About 30% of the proteins in the cell are regulated in this way. A complex network called the mitotic kinase network regulates the phosphorylation and dephosphorylation of proteins involved in mitosis. This network ensures mitosis can progress successfully.

This image was made in response to research by Iain Hagan