The Drosophila ventral furrow is internalised to form a tube in the middle of the embryo. This marks the start of gastrulation.
The physical shape and size of a tissue as a whole is the product of the internal forces in thousands of individual cells. Studying the ventral furrow development in Drosophila embryo canthe unde help understand the underlying principles of tissue organisation.
The formation of the Drosophila ventral furrow involves not only the cells which make up the furrow, but also the communication and cooperation of multiple neighbouring cell types. Simultaneous time-lapse imaging can be used alongside genetic and chemical modification to follow gastrulation and investigate what factors impact development of the furrow.
This image was inspired by research by Maria Leptin.