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The Anaphase Promoting Complex

The Anaphase Promoting Complex (APC/C) is a multimeric protein crucial in the regulation of the cell cycle. It is particularly important in chromosome segregation and mitotic exit.

The atomic structure of the APC/C has been determined using cryo-electron microscopy, a fast developing structural biology technique used to solve the native structures of protein complexes. Resolving the structure of the proteins which make up the APC/C has enabled atomic-level understanding of the architechure of the complex and how this influences function. The APC/C plays an important role in the control of the eukaryotic cell cycle, particularly the segregation of chromosomes and mitotic exit. Greater structural understanding lays the foundation for future experiments examining the functions of the APC/C.

This image was inspired by research by David Barford.