Charlie Boone

The genetic landscape of a cell

The Boone lab map genetic interaction networks within cells. The take the model organism S. cerevisea (budding yeast) and investigate synthetic lethal interactions between genes. Synthetic lethality looks at combinations of gene knockouts where the organism can survive if just one gene is knocked out, but both in combination are lethal. These instances usually suggest that the two genes produce products that are used in similar pathways. Loss of function of one gene can be compensated by upregulating the other gene, but loss of both is much more serious. The illustration here mirrors the style of network map illustration used by the Boone lab, but draws an image of an S cerevisea cell with it rather than a functional network.